Original Research Article
Year: 2018 | Month: August | Volume: 5 | Issue: 8 | Pages: 149-159
Fabrication & Evaluation of Ketoprofen Loaded Cubogel for Topical Sustained Delivery
Karthika V T, Sheri P.S, Dr M.A Kuriachan
Department of Pharmaceutics, Mar Dioscorus College of Pharmacy, Thiruvananthapuram, Kerala
ABSTRACT
The present study is concerned with the development and characterization of a novel nanoparticulate system; cubosomes, of Ketoprofen loaded hydrogel to reduce the gastro intestinal effects with sustaining bioavailability. Cubosome dispersions were formulated by top-down technique using different concentrations of lipid phase monoolein, non ionic surfactant poloxamer 407 and water as aqueous phase. The prepared cubosomal dispersions were characterized regarding physical morphology, dimensional distribution by TEM, particle size by dynamic light scattering, entrapment efficiency and in vitro drug release. The optimum formulae were incorporated in a carbopol 934 based hydrogel to form cubosomal hydrogel (cubogel). The cubogel were characterized along with drug loaded plain gel regarding in physical examination, pH, % drug content, skin irritancy study, viscosity, spreadability studies, and in vitro drug release studies. Overall development of topical forms of ketoprofen is relevant due to its poor aqueous solubility and GI side effects. The ketoprofen-loaded cubosomes propose a promising system for treatment of arthritis simply through skin application.
Key words: Cubosomes, Ketoprofen, Poloxamer 407, Hydrogel , Arthritis
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