Original Research Article
Year: 2019 | Month: June | Volume: 6 | Issue: 6 | Pages: 11-17
Association of Vitamin D Status with Polycystic Ovary Syndrome in Relation to Insulin Resistance and Serum Total Testosterone
Pritam Kumar Saha1, Santasmita Pal2, Tapan Mukhopadhyay3
1Ex PGT, Department Of Biochemistry, Medical College, Kolkata
2Assistant Professor, Department Of Biochemistry, Medical College, Kolkata
3Professor and Head, Department Of Biochemistry, Medical College, Kolkata
Corresponding Author: Santasmita Pal
ABSTRACT
Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among women. Insulin resistance is now recognized as an integral component, particularly in obese. Association of vitamin D status with metabolic and hormonal dysfunction in PCOS has been investigated by some studies but the relationship between them still remains to be conclusive. The link between altered vitamin D status (if any) and androgen excess may have dependence on insulin resistance associated with PCOS.
Aims and objectives: The present study aims to find out interrelationship between serum Vit.D, Total Testosterone levels and Insulin resistance in PCOS cases.
Materials and methods: The study included 150 PCOS patients from Gynaecology and Endocrinology OPD of a tertiary care hospital of Kolkata, West Bengal, and 150 age- matched healthy volunteers. Serum 25(OH) Vit D, total testosterone and insulin levels were estimated by Enzyme Linked Immunosorbent Assay (ELISA) method. Insulin resistance was calculated from fasting serum insulin and fasting plasma glucose level with HOMA-IR formula (Homeostasis Model Assessment of Insulin Resistance).
Results: Our study revealed that serum vitamin D levels were significantly lower in PCOS cases in comparison to age matched control group. Significant negative correlation of vitamin D status was found with insulin resistance and androgen status in PCOS cases.
Conclusion: Though this is a small study, it has provided some clue into pathophysiology of PCOS. The relations and associations achieved from the results of this study sustained this explanation and so our study hints that vitamin D may have a decisive role in PCOS and has a potential to emerge as an associated biochemical parameter of PCOS.
Key words: Vitamin D, Insulin Resistance, Total Testosterone, Polycystic Ovary Syndrome.
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