Original Research Article
Year: 2019 | Month: June | Volume: 6 | Issue: 6 | Pages: 294-302
Assessment of Safe Neuromuscular Reversibility after Vecuronium Bromide with and without Neostigmine
Dr. Satyendra Kumar Gahlot1, Dr. Sanjeev Ahuja2
1Associate Professor, 2Assistant Professor;
Dept. of Anaesthesia, GSVM Medical College, Kanpur
Corresponding Author: Dr. Sanjeev Ahuja
ABSTRACT
Postoperative residual neuromuscular block is a frequent occurrence in the practice of anaesthesia. There is convincing evidence that quantitative neuromuscular monitoring reduces the frequency of residual neuromuscular block in patients receiving non-depolarizing neuromuscular blocking agents. The present study has investigated the recovery from vecuronium bromide induced neuromuscular block with & without anticholinesterase drug "Neostigmine" in 60 cases. In our study we have included the age group from 10-70 years with mean age of 35.33 years of group A and mean age of 32.83 of Group B. We have included the patients of both sexes with male/female ratio 21:9 in group A and 16:14 in group B. All the patients were allocated randomly in two groups. Group A with 30 patients received neostigmine in dose of 0.04 mg/kg was to reverse vecuronium bromide induced neuromuscular block while group B of 30 cases did not receive neostigmine. Result shows that evoked recovery from vecuronium bromide induced neuromuscular block was most rapid & adequate after 0.04 mg/kg neostigmine. Recovery was prolonged & incomplete when neostigmine was not given for reversal of vecuronium induced neuromuscular block and omission of neostigmine would clearly be unsatisfactory. Vecuronium bromide did not show any significant effects on cardiovascular system. There was slight increase in pulse rate & arterial blood pressure after intubation which returned to normal value after 5-10 minutes. There was no side effect of neostigmine in dose of 0.04 mg/kg given for reversal.
Key words: Neuromuscular reversibility, neuromuscular blocking agents, vecuronium bromide, neostigmine
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