Original Research Article
Year: 2021 | Month: December | Volume: 8 | Issue: 12 | Pages: 1-6
DOI: https://doi.org/10.52403/ijrr.20211201
Vascular Endothelial Growth Factor (VEGF) -460C/T (rs833061) Gene Polymorphism as a Risk Factor for Diabetic Retinopathy in Type 2 Diabetes Mellitus in Bali
Astri Meliana1, Desak Made Wihandani2, Ni Nyoman Ayu Dewi2, I Made Winarsa Ruma2, Anak Agung Mas Putrawati Triningrat3
1Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia, 80113
2Biochemistry Department, Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia, 80113
3Ophthalmology Department, Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia, 80113
Corresponding Author: Anak Agung Mas Putrawati Triningrat
ABSTRACT
Introduction: Diabetic retinopathy (DR) is a microvascular disorder of the retina caused by hyperglycemia in the blood vessels and is the most common complication in the eye due to diabetes mellitus (DM). The aim of this study was to determine the VEGF -460C/T gene polymorphism as a risk factor for diabetic retinopathy in T2DM patients in Bali.
Materials and Methods: The design of this study was case-control with 27 cases of type 2 DM with DR and 29 cases without RD as controls. The VEGF-460C/T polymorphism in DNA was detected using PCR and DNA sequencing at rs833061 to see the distribution of the C/T allele variation. Data were analyzed using chi-square test.
Results: Based on bivariate analysis comparing homozygous TT genotype variants, heterozygous CT and wild-type CC in this study, no significant relationship was found with the incidence of DR (p=0.742).
Conclusion: Polymorphism of the VEGF-460C/T gene (rs833061) can be concluded as an irrelevant factor with the risk of developing DR in type 2 diabetes mellitus patients in Bali.
Keywords: VEGF -460C/T, Diabetes Mellitus, Polymorphism, Risk Factors.
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