Review Article
Year: 2021 | Month: July | Volume: 8 | Issue: 7 | Pages: 481-485
DOI: https://doi.org/10.52403/ijrr.20210768
Multisystem Inflammatory Syndrome in Children; an Emerging Global Threat - A Review
AR Shabaraya1, Archana KU2
1Professor & Head, 2Student Pharm D, Department of Pharmacy Practice, Srinivas College of Pharmacy, Valachil, Mangalore, Karnataka-574143
Corresponding Author: Archana K U
ABSTRACT
MIS C (Multisystem Inflammatory Syndrome in Children) is a disease related to post COVID-19 sequelae. Differential diagnosis includes Kawasaki disease, Bacterial sepsis, toxic shock syndrome, Appendicitis, Macrophage activation syndrome. Clinical Presentations include high grade fever, rashes, Gastrointestinal symptoms like (abdominal pain, vomiting, diarrhea), hypotension and shock. The pathogenesis of MIS-C is unknown, and a postinfective etiology has been hypothetical but unproven. Antibodies to SARS-CoV-2 appear in the second week following infection, although their existence does not suggest infection resolution. Laboratory markers of inflammation, such as CRP, are elevated. IVIG, Glucocorticoids such as methyl prednisolone, Antibiotics, thromboprophylaxis with Light Molecular Weight Heparin are the management options. Since the available information doesn't allow to formulate well-established guidelines or recommendations for MIS-C treatment, and therefore the long-term sequelae of the illness aren't yet known.
Keywords: MIS C, IVIG, Kawasaki disease.
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