Review Article
Year: 2023 | Month: April | Volume: 10 | Issue: 4 | Pages: 26-30
DOI: https://doi.org/10.52403/ijrr.20230405
Pseudo-ceramides as A Novel Therapy in Overcoming Xerosis Cutis in Geriatric Population with Chemotherapy and Radiotherapy: A Review Article
Claudia Felicia Limanda1, Susy Purnawati2
1Faculty of Medicine, Udayana University, Denpasar, Indonesia
2Department of Physiology, Faculty of Medicine, Udayana University, Denpasar, Indonesia
Corresponding Author: Claudia Felicia Limanda
ABSTRACT
Background: Xerosis Cutis is a common condition in geriatric population identified by the loss of water and oil to a certain level that resulted in the decrease of moisture and the increased possibility for more serious skin complications. This condition is considered harmless, however, when untreated leads to other skin problems such as skin cracking and bleeding, eczema reactivation, and skin infection. In addition, elderly is also prone in experiencing cancer that when treated with chemotherapy and radiotherapy can destroy healthy skin cells alongside cancer cells, making skin redder, darker, drier, and itchier. According to existing studies, the decrease of ceramides in stratum corneum is a contributing factor that cause dry skin in elderly. Pseudo-ceramides, being a synthetic type of ceramides that can replace skin natural ceramides, are believed to be effective in preventing and treating Xerosis Cutis. Therefore, authors want to further explain the effectiveness of pseudo-ceramides in the treatment of Xerosis Cutis, especially in elderly experiencing chemotherapy and radiotherapy.
Method: This review article is composed of articles from renowned sources such as PubMed, Karger Publishers, National Library of Medicine, ResearchGate, and others using keywords such as “Dry skin”, “Skin cancer”, “Elderly”, and “Pseudo-ceramides”. Information is then accessed for its validity, reliability, and compatibility with the study theme before compiled into this article.
Result: Based on studies using elderly population as test subjects, symptoms such as scaling, itchiness, erythema, dryness, and roughness improved in 3-4 weeks after topical application of pseudo-ceramides. Inflammatory cells also significantly decrease.
Conclusion: It is proved that pseudo-ceramides can act as an anti-inflammatory agent and reduce Xerosis Cutis and other complications related to this condition.
Keywords: [Dry Skin, Skin Cancer, Elderly, Pseudo-ceramide]
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