Review Article
Year: 2023 | Month: May | Volume: 10 | Issue: 5 | Pages: 455-464
DOI: https://doi.org/10.52403/ijrr.20230552
Neurodegenerative Disorders Through the Lens of Optogenetics
Saksham Sharma1, Claudia Valeria Rivera Cazaño2, Aditi Singh3, Komudi Sapru4, Trisha Kesavan5, Chidurala Rahul6
1Student, Department of medicine; I. Ya Horbachevsky Ternopil National Medical University, Ukraine
2Student, Department of medicine; Peruvian University Cayetano Heredia, Peru,
3Student, Department of medicine; Saraswati Medical College, India,
4Student, Department of medicine; Saraswati Medical College, India,
5Student, Department of Medicine, SRM Medical College Hospital and Research Centre, India
6Student, Department of medicine; Sri Ramachandra Institute Of Higher Education And Research, India
Corresponding Author: Saksham Sharma
ABSTRACT
Neurodegenerative disorder, as the name suggests, encompasses progressive neuronal degeneration that renders patients with a lack of, or at the very least dysfunctional cognition, motor senses, and bodily functions. The progressive worsening of the condition in conjugation with the lack of therapeutic measures makes them very difficult to bear.
Optogenetics, as discussed below, offers an approach that has contributed to the research for a solution to neurological degeneration at two fronts. The tools in the disciple help us employ microbial opsins to gain pinpoint control over neuronal firing. Furthermore, the engagements after an inhibitory or stimulatory control have been gained over neural circuitry have been insightful in understanding the progression of neurological pathologies. The following review will delve into the therapies available for Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Huntington's Disease, Multiple sclerosis (MS), and Parkinson's Disease and explore the research insights.
Keywords: Optogenetics, Neurodegenerative disorders, Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Huntington’s Chorea
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