Original Research Article
Year: 2023 | Month: June | Volume: 10 | Issue: 6 | Pages: 657-664
DOI: https://doi.org/10.52403/ijrr.20230680
Correlation Between Free Triiodothyronine (FT3) with PELOD-2 Score and PICU Length of Stay in Critically Ill Pediatric
Mohd Luthfi B1, Eka Agustia Rini2, Mayetti3
1Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
2Endocrinology Subdivision, Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
3Pediatric Emergency and Intensive Care Subdivision, Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
Corresponding Author: Mohd Luthfi B
ABSTRACT
Background: Thyroid function disorders, particularly reduced FT3 levels, are frequently observed in critically ill patients. FT3 plays a crucial role in metabolic regulation during critical illness. The extent of the decrease in FT3 levels directly corresponds to the severity of the disease, as indicated by the PELOD-2 score, and indirectly influences the length of stay in the Pediatric Intensive Care Unit (PICU). This study aims to examine the relationship between free triiodothyronine (FT3) levels and both the PELOD-2 score and the length of stay in critically ill pediatric patients.
Methods: Cross-sectional study was conducted at Dr. M Djamil Hospital's Pediatric Intensive Care Unit (PICU) from June to September 2022. The study included critically ill pediatric patients who accept the informed consent and were well-nourished, while individuals with a history of thyroid disease, those using exogenous/thyroid hormone/antithyroid drugs, individuals with chronic diseases, and those with Down's syndrome were excluded. The levels of FT3 and PELOD-2 scores were measured within 48 hours of admission, while the length of stay was obtained from medical records. Data analysis was performed using the SPSS program, utilizing the Spearman correlation test.
Result: Thirty subjects were included in the study. The mortality rate was 30%. The median FT3 level was 1.5 pg/mL. FT3 levels were low in 26 of 30 samples. There was a significant negative correlation (p = 0,001) between FT3 levels and PELOD-2 scores with moderate value (r = -0.567) and no significant correlation between FT3 levels and PICU length of stay.
Conclusion: The lower FT3 level measured, the higher PELOD-2 score found in critically ill children.
Keywords: FT3, PELOD-2 score, length of stay, critically ill pediatric
[PDF Full Text]