Original Research Article
Year: 2023 | Month: June | Volume: 10 | Issue: 6 | Pages: 720-728
DOI: https://doi.org/10.52403/ijrr.20230685
Comparative Evaluation of Antibacterial Efficacy of Cetylpyridinium Chloride and Chlorhexidine Gluconate Mouthwashes after Periodontal Surgery - A Randomized Clinical Study
Dr Mugdha Mangaonkar1, Dr Ashvini M Padhye2
1PG student, Department of Periodontics, 2Head of department of Department of Implantology,
MGM Dental College, MGM University, Mumbai, India
Corresponding Author: Dr Mugdha Mangaonkar
ABSTRACT
Background: Periodontitis affects 20-50 percent population is and has various systemic interrelationship. Treatment of periodontal disease requires a holistic approach. Prevention of bacterial accumulation at surgical site is crucial to minimize post-operative complications. The principal cause of post-surgical infection is bacterial colonization due to the wicking effect of the sutures. Despite numerous factors, pathogenic biofilm formation continues to play a crucial role in disease progression. Hence, a comprehensive approach with the goals of infection control, periodontal tissue regeneration, and function restoration becomes a necessity. In this study, we assessed the antibacterial efficacy of Chlorhexidine (CHX) and Cetylpyridinium Chloride (CPC) mouthwashes after periodontal surgery.
Material and Methods: In this single-centric, prospective, randomized study, patients undergoing various periodontal surgeries including flap procedures, crown lengthening, resective osseous surgeries, implant placement and periodontal plastic procedures following placement of simple interrupted sutures using monofilament PTFE sutures to reduce the wicking effect. Patients included were >18 years of age, while those with any systemic diseases, pregnant and lactating women, smokers or any other deleterious habits, immune and mental disorders, unwilling to participate were excluded from the study. A total of 46 patients were randomized using envelope method to either one of the two types of mouthwashes CHX or CPC for 10 days post-periodontal surgeries and the sutures were removed after 10 days for CFU analysis.
Results: Out of total 46 participants more than half were males (26) and the mean age of participants was 32.53 years (range 18-65 years). Maximum periodontal surgeries were flap procedures (21) and crown lengthening (15) while remaining included osseous surgery (5), perioplastic procedures (3) and implant procedures (2). There was a statistically significant difference seen for the values between the groups. Group I CPC had average CFU count (Mean 1.2x1010) Group II CHX had (Mean 1.2x108) The p value of Mann-Whitney U test was <0.01.
Conclusion: Though the bacterial load was reduced by both types of mouthwashes, our study observed better antibacterial effectivity with CHX as compared to CPC. The findings of the study also highlighted the importance of careful adjuvant therapies regardless of the type of periodontal surgery.
Keywords: Periodontal surgery, Cetylpyridinium chloride, Chlorhexidine gluconate, mouthwashes, periodontitis, biofilm, Plaque, Wound healing.
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