IJRR

International Journal of Research and Review

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Review Article

Year: 2023 | Month: August | Volume: 10 | Issue: 8 | Pages: 303-314

DOI: https://doi.org/10.52403/ijrr.20230838

Revolutionary Target-Based Approaches Inscribing the Pathogenesis of Psoriasis

Mansi Dobariya1, Sunita Goswami2

1,2Department of Pharmacology, L.M. College of Pharmacy, Gujarat Technological University, Ahmedabad, India

Corresponding Author: Dr. Sunita Goswami

ABSTRACT

Psoriasis is a chronic, non-communicable, painful, disfiguring, and disabling disease for which there is no cure and it considerably affects a patient’s quality of life. This article has considered an in-depth review using various search methodologies which describes the pathogenesis of psoriasis and target-based approaches. The findings in pathogenesis include many approaches from epidermal hyperplasia to immune-mediated, chronic inflammatory, genetic and autoimmune mechanisms. Psoriasis seems to be a feedback system of immune cells running beneath the skin. The development of precisely targeted therapy is possible with a detailed understanding of disease pathophysiology. So, the present review comprises insights into pathophysiology and target-based approaches for psoriasis therapy.

Keywords: Pathogenesis, Targets, Immune cells, cellular mechanisms, Signal transduction pathways, biologics

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