Year: 2023 | Month: September | Volume: 10 | Issue: 9 | Pages: 138-147
DOI: https://doi.org/10.52403/ijrr.20230914
Correlation between Ferritin Level and NT-ProBNP in Thalassemia Patient at M. Djamil Hospital Padang
Diyas Anugrah1, Didik Hariyanto2, Amirah Zatil Izzah3, Rinang Mariko4, Gustina Lubis5, Asrawati6, Rahmi Lestari7
1Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
2Cardiology Subdivision, Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
3Hematology and Oncolgy Subdivision, Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
4Infectious and Tropical Disease Subdivision, Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
5Nutritional and Metabolic Disease Subdivision, Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
6Growth and Development-Social Subdivision, Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
7Neurology Subdivision, Department of Pediatric, Faculty of Medicine, Universitas Andalas, Indonesia
Corresponding Author: Diyas Anugrah
ABSTRACT
Background: Thalassemia is a hereditary haemolytic anaemia caused by a genetic defect in the formation of globin chains. Routine blood transfusion is part of the management of thalassemia in Indonesia to maintain haemoglobin levels above the target haemoglobin. The consequence of this therapy is secondary excess of iron (ferritin), which adversely affects cardiac function. NT-pro BNP is one of the cheaper, more accessible, and non-invasive biomarkers that can be used to detect abnormalities in cardiac function. This study aims to analyse the correlation of ferritin levels with NT-proBNP in thalassemia patients.
Method: This is an observational analytic study with a cross sectional approach. The inclusion criteria in the study were thalassemia patients who were ≤18 years old and routinely received repeated transfusions. Patients with a history of congenital heart disease, heart failure, hyperthyroidism, overt valvular disease, sepsis, or chronic kidney disease were excluded from this study. Correlation analysis was carried out by analysing the relationship between ferritin levels and NT-proBNP levels in children with thalassemia at RSUP Dr. M Djamil Padang.
Result: A total of 27 children were included in this study. The median ferritin level of the samples was 3,465.00 (range 1,100-13,600) ng/ml. The median NT-Pro BNP level of the samples was 4.7767.00 (range 3.503-11.575). The results of the correlation analysis showed a significant positive correlation (p = 0.039) with a weak strength level (r = 0.399) between ferritin levels and NT-ProBNP levels.
Conclusion: There is a significant correlation between ferritin levels and NT-proBNP.
Keywords: Ferritin, NT-proBNP, Thalassaemia
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