Year: 2023 | Month: September | Volume: 10 | Issue: 9 | Pages: 320-335
DOI: https://doi.org/10.52403/ijrr.20230933
Obesity and Diabetes Mellitus 2: Interrelated Relative Relationship
Maitham Abdallah Albajy1,2, Dan Florin Mihailescu11,3
1Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania
2National Center for Occupational Health and Safety, Dhi Qar City, Iraq
3Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, 10 Șoseaua Berceni Str., 041914 Bucharest, Romania
Corresponding Author: Maitham Abdallah Albajy
ABSTRACT
Obesity, defined as the excessive accumulation of body fat, is determined using body mass index (BMI) classifications. This condition is a primary contributor to several severe health issues, encompassing heart diseases, diabetes, hypertension, and specific cancers. Predominantly, environmental influences and lifestyle choices, such as inactive behaviors and unhealthy diets, are the culprits behind obesity. Common therapeutic interventions for obesity include dietary modifications, physical activity, and in some cases, medications or surgical procedures.
A heightened BMI can signal the potential onset of Type 2 diabetes, given that an increased fat percentage elevates the risk of this disease. Globally, obesity rates have surged, positioning it as a top health concern and a notable medical condition. This rise is largely attributed to the widespread adoption of poor dietary practices and inactive lifestyles. Consequently, there's a parallel increase in Type 2 diabetes cases, especially among those labeled as "extremely obese."
The relationship between obesity and Type 2 diabetes is intricate, stemming from complex cellular and physiological interactions. These interactions influence beta cell functions, modify the biology of fat tissues, and amplify insulin resistance. Given the multifaceted link between obesity and Type 2 diabetes, it's imperative to consider this when formulating efficient prevention and treatment methodologies. Notably, due to shifts in the functionality of pancreatic beta cells, the nature of adipose tissue, and insulin resistance, adults with significant weight gains are predisposed to Type 2 diabetes. Addressing this escalating health challenge necessitates strategies focusing on both weight management and metabolic health optimization.
Keywords: Obesity, Type 2 Diabetes, Insulin resistance, Adipose tissue, Free fatty acid
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