Year: 2023 | Month: September | Volume: 10 | Issue: 9 | Pages: 569-576
DOI: https://doi.org/10.52403/ijrr.20230959
Design and Evaluation of Chitosan Nanoparticles as Novel Drug Carriers for the Delivery of Gamma Oryzanol
Vivek Kumar Patel1, Rajsekaran S.2
1,2Bhagwant University, Ajmer, Rajasthan
Corresponding Author: Vivek Kumar Patel
ABSTRACT
Background: Gamma oryzanol has been studied for its potential health benefits, including its use in managing arthritis and other inflammatory conditions. Chitosan, a biopolymer derived from chitin, has gained significant attention in the field of drug delivery and biomedical applications due its unique properties biocompatibility, biodegradability, and low toxicity.
Objective: The aim of this research was to prepare and analyse gamma oryzanol nanoparticle by using chitosan biopolymer.
Material & Method: Chitosan was taken as biopolymer in order to make nanoparticle by using ion gelation method. Gammaoryzanol loaded nanoparticles were subjected to evaluation for particle size analysis, XRD, % entrapment efficiency, drug content encapsulation efficiency, and % drug diffusion.
Result & Discussion: Prepared Gammaoryzanol nanoparticles were showed particle size in the range of (116.8) to (227.5) d-nm, less intensity of the diffraction peak when compared to that of gamma oryzanol, drug content in the range 38.67% to 73.19% (w/w), encapsulation efficiency in the rage of 46.58% to 71.31%. Percentage of drug Released after 6 h ranged from 70.14% to 93.79%. Among all the formulation, F9 was found to be optimized formulation in all the aspects.
Keywords: Gammaoryzanol, Nanoparticle, Chitosan, Biopolymer.
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