Year: 2024 | Month: October | Volume: 11 | Issue: 10 | Pages: 145-158
DOI: https://doi.org/10.52403/ijrr.20241014
Prevalence of Chronic Obstructive Pulmonary Disease Exacerbation with Heart Failure Comorbid: A Systematic Review and Meta-Analysis
La Ode Muhammad Nazar Ghazali Yusuf1, Muhammad Ilyas1, Faisal Yunus1, Nirwana Fitriani Walenna2, Edward Pandu Wiriansyah1, Sitti Nurisyah1, Erwin Arief1
1Pulmonology and Respiratory Medicine Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
2Anatomy Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Corresponding Author: La Ode Muhammad Nazar Ghazali Yusuf
ABSTRACT
Heart Failure (HF) is one of the comorbidities in Chronic Obstructive Pulmonary Disease (COPD), associated with the incidence of respiratory tract infections which is a risk factor for COPD exacerbations. Eleven studies conducted in the meta-analysis. Pooled prevalence of COPD exacerbations with HF comorbidity was 29,43 % (95%CI:17,68%- 42,92%) and statistical heterogenity among the eleven studies was significant (I2 = 99,95%. Q = 191,96 p=<0,001). Eight studies were based in Europe, two studies in Americas and one study in Asia. Prevalence of COPD exacerbations with HF comorbidity based on WHO region subgroup analysis found European region 31,44% (95%CI: 17,87%-46,58%), America’s region 32,92% (95%CI: 12,61%-55,73%) and the Western Pacific region 10,86% (95%CI:10,03%- 13,21%) with significant statistical heterogeneity (I2 = 99,94%, Q = 191,96, p= <0,001). The age of exacerbating COPD patients with comorbid heart failure was above 70 years and there were differences in gender characteristics based on the two studies that reported. Statins reduce the incidence of COPD exacerbations. Differences in the risk of COPD exacerbation receiving Angiotensin Converting Enzyme Inhibitor/Angiotensin Receptor Blocker (ACEi/ARB) therapy. The most common comorbid cardiovascular disease apart from heart failure are atrial fibrillation and ischemic heart disease. As a conclusion, the pooled prevalence of COPD exacerbations with heart failure comorbid in this systematic review and meta-analysis was 29.43% (95% CI:17.68%-42.92%).
Keywords: COPD exacerbation, Heart Failure, prevalence
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