Year: 2024 | Month: October | Volume: 11 | Issue: 10 | Pages: 441-444
DOI: https://doi.org/10.52403/ijrr.20241039
Association of Chronic Obstructive Pulmonary Disease Exacerbation with Type-2 Diabetes Mellitus Comorbidity: Possibility Role of IL-8
Armita Dewi1, Faisal Yunus2, Nirwana Fitriani Walenna3, Irawaty Djaharuddin4, Arif Santoso5, Nur Ahmad Tabri6, Muhammad Ilyas7
1Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia
2Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jakarta, Indonesia
3Department of Anatomy, Faculty of Medicine, University of Hasanuddin, South Sulawesi, Indonesia.
4Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia
5Departement of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia
6Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia
7Departement of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia
Corresponding Author: Armita Dewi
ABSTRACT
Introduction: Type-2 Diabetes Mellitus (type-2 DM) is associated with the incidence of respiratory tract infections which is a risk factor for Chronic Obstructive Pulmonary Disease (COPD) exacerbations. Interleukin-8 (IL-8) is one of inflammatory mediators both in COPD exacerbation and pathogenesis of type 2 DM.
Method: We conducted literature searched in online database PUBMED and Google Sholar, all study published since 2015 until 2024.
Conclusions: IL-8 is a proinflammatory cytokine that has been shown to play a role in COPD because it triggers mucus hypersecretion and bacterial colonization which is risk factor for exacerbation of COPD and causes adipose tissue dysfunction in type 2 diabetes.
Keywords: COPD exacerbation; type-2 DM; prevalence; IL-8
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