Year: 2024 | Month: November | Volume: 11 | Issue: 11 | Pages: 308-313
DOI: https://doi.org/10.52403/ijrr.20241126
The Effect of Sungkai (Peronema canescens Jack) Leaf Extract on Malondialdehyde Levels in Diabetic Rats Model
Indah1, Rauza Sukma Rita2, Gestina Aliska3
1Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
2Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
3Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Corresponding Author: Rauza Sukma Rita
ABSTRACT
The chronic illness known as diabetes mellitus is typified by elevated blood glucose levels brought on by an insulin shortage, or hyperglycemia. Oxidative stress is caused by hyperglycemia, which also deactivates the antioxidant system and causes reactive oxygen species (ROS) to build up. Lipid peroxidation is brought on by this stress, and malondialdehyde (MDA) is one of the by-products. This study used a diabetic rat model to examine how sungkai leaf extract affected MDA levels. This study used 30 rats in six groups: negative control (NC), positive control (PC) with alloxan induction, diabetes control (DC) with glibenclamide, and administration of sungkai (Peronema canescens Jack) leaf extract T1 (Dose 150 mg/kgBW), T2 (Dose 300 mg/kgBW), and T3 (Dose 600 mg/kgBW) for 30 days. The study was experimental and used a post-test-only control group design. The TBARS method was used to measure MDA levels. The One-way ANOVA test and the Bonferroni Post Hoc test were used to evaluate the data. According to the findings, MDA levels were considerably lowered by the sungkai leaf extract. It can be concluded that sungkai leaf extract lowers MDA levels in a model of diabetic rats.
Keywords: Diabetes Mellitus, Hyperglycemia, Malondialdehyde, Peronema canescens Jack.
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