Year: 2024 | Month: December | Volume: 11 | Issue: 12 | Pages: 1-6
DOI: https://doi.org/10.52403/ijrr.20241201
Sungkai Leaf Extract (Peronema canescens Jack) Decrease Blood Glucose Levels in Rat Models of Diabetes Mellitus
Siski Rahayu1, Rauza Sukma Rita2, Mohamad Reza3
1Master Programme in Biomedical Sciences, Faculty of Medicine, Universitas Andalas, Padang Indonesia.
2Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang, Indonesia.
3Department of Biology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia.
Corresponding Author: Rauza Sukma Rita
ABSTRACT
Diabetes mellitus (DM) is a long-term metabolic condition marked by hyperglycemia, which, if it persists, will generate an excess of free radicals, contributing to problems from diabetes. Sungkai (Peronema canescens Jack) is a plant that provides antioxidants and antidiabetic properties. Finding out how sungkai leaf extract affects blood glucose levels in diabetic rat models is the aim of this study.
In this study, the Post Test-Only Control Group is used as part of an experimental design. The 35 rats were split up into six groups: the DM control group (KDM) of rats given glibenclamide, the positive control group (K+) of rats given alloxan, the negative control group (K-), and the group that received sungkai leaf extract (Peronema canescens Jack) P1 (dose 150 mg/kgBB), P2 (dose 300 mg/kgBB), and P3 (dose 600 mg/kgBB) for 30 days. Using a spectrophotometer and the GOD-PAP technique, blood glucose levels were assessed.
According to the findings, sungkai leaf extract (Peronema canescens Jack) reduced blood glucose levels (p<0.05). In summary, sungkai leaf extract may be used as an antidiabetic treatment.
Keywords: Hyperglycemia, Sungkai Leaf Extract, Antidiabetic
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