Year: 2024 | Month: December | Volume: 11 | Issue: 12 | Pages: 188-193
DOI: https://doi.org/10.52403/ijrr.20241222
Relationship of Interleukin (IL-10) Level to Sputum Conversion and Influence Factors in Drug-Resistant Tuberculosis
Irawaty Djaharuddin1, Harun Iskandar1, Nur Ahmad Tabri1, Erwin Arief1, Jamaluddin Madolangan1, Etien Andriani1
1Department of Pulmonology and Respiratory Medicine, Medical Faculty Hasanuddin University-Dr. Wahidin Sudirohusodo General Hospital Makassar, Indonesia
Corresponding Author: Irawaty Djaharuddin
ABSTRACT
Introduction: Pulmonary tuberculosis (TB) is an infection causative agent of Mycobacterium tuberculosis. Indonesia is in fifth place with drug-resistant tuberculosis. The achievement of TB management is surprisingly dependent on the analysis, suitable remedy, and comparing its remedy. Many TB patients who are present process similarly anti-tuberculosis remedies have issued sputum elimination for acid-resistant bacillus smear examination so that the healing display is not optimal.
Objective: The study analyzes the relationship between interleukin 10 (IL-10) level and sputum conversion and influence factors in drug-resistant tuberculosis.
Methods: A total of 45 resistance tuberculosis mycobacterium with inclusion criteria are 18-65 years old, shorter regimen, acid-fast bacilli sputum conversion, and serum IL-10 levels were recorded in the medical record—the research analytic observational with a retrospective cohort design.
Results: Interleukin 10 levels show that the higher the anti-inflammatory response, the faster the sputum conversion occurs. It can be a marker of the weakened immune response of Th1 to MTB infection. Based on the AFB sputum conversion, other studies supported that the increase of IL-10 levels in serum could be used as a prognostic marker of the therapeutic success of TB. Cut off point IL-10 level in this study was 5,83 pg/ml with 94,29% sensitivity and 100% specificity in predicting conversion time.
Conclusion: The higher IL-10 production in TBRO indicates suppression of immune response. Comorbid factors of diabetes mellitus and initial bacterial load affect the sputum conversion influence of TBRO patients.
Keywords: Interleukin 10, influence factor, TBRO, conversion
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