Year: 2024 | Month: December | Volume: 11 | Issue: 12 | Pages: 631-642
DOI: https://doi.org/10.52403/ijrr.20241268
The Anticancer Potential of Gold Nanoparticles from Flavonoid Fractions of Soursop Leaves (Annona muricata) Polymerized with PLGA on HER-2 Receptor Expression in Breast Cancer: A Literature Review
Farhan Aqsha Alghani1, Muhammad Rifqi Al Azim1, Rauza Sukma Rita2
1Medical Doctor Study Program, Faculty of Medicine, Universitas Andalas, Padang, Sumatera Barat, Indonesia.
2Department of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang, Sumatera Barat, Indonesia
Corresponding Author: Rauza Sukma Rita
ABSTRACT
Breast cancer is a malignant disease affecting cells in the breast tissue, causing the highest mortality rate among women worldwide. As of now, the exact cause of breast cancer remains unknown, but several factors increase the risk for women, including genetics, lifestyle, direct radiation exposure, and others. In the development of breast cancer, numerous substances can influence the differentiation, adhesion, and motility of cancer cells, including the oncogene human epidermal growth factor receptor-2 (HER-2). Various treatment methods for cancer have been developed, including chemotherapy, radiotherapy, and surgery. However, due to the significant side effects and limitations of existing treatments, innovation is needed to support the success of breast cancer treatment. Recent research has explored green synthesis-based gold nanoparticles (AuNPs) as a promising alternative anticancer therapy with several advantages. The rapid growth of natural herbal plants containing anticancer compounds like flavonoids can enhance the effectiveness of modified therapies in this modern era. The polymerization of gold nanoparticles with flavonoid fractions using Poly-Lactic-co-Glycolic Acid (PLGA) can facilitate the delivery of anticancer drugs to the target site. The research method employed is a literature review using e-resources from PubMed NCBI, ScienceDirect, and Google Scholar. Keywords include Gold Nanoparticle, Breast Cancer, flavonoid, PLGA. Article criteria include full text, abstract, and publication within the last ten years (2013-2024). A total of 157 articles were obtained, and 7 articles were found to be relevant to the topic. Literature review results indicate the high anti-oncogenic effectiveness of gold nanoparticles with flavonoid-polymerized PLGA for breast cancer treatment. This finding can serve as a reference for the application of molecular therapeutic development that has proven to influence the suppression of HER-2 receptor growth expression.
Keywords: Gold Nanoparticle, Breast Cancer, Flavonoid, PLGA, HER-2
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