Year: 2024 | Month: February | Volume: 11 | Issue: 2 | Pages: 18-29
DOI: https://doi.org/10.52403/ijrr.20240204
Hyperuricemia Is Equivalent to Type 2 Diabetes - Transforming Myth into Reality
Dr. G R Subbu
Chief, Department of Medicine, St. Joseph's Hospital, Poovathussery, Parakkadavu. P.O, Ernakulam - 693579, Kerala, India.
ABSTRACT
Hyperuricemia is a metabolic disorder characterized by a high level of uric acid in the blood and was commonly thought to be associated with gout and nephrolithiasis. While hyperuricemia and T2D (Type 2 diabetes) are distinct medical conditions, they share certain similarities, and both have significant detrimental effects on humans. The prevalence of hyperuricemia and T2D has been alarmingly rising in the past two decades, and the development of these two conditions among young adults is worrisome for healthcare professionals. Research and debates have recently focused on a possible link between hyperuricemia and T2D. Individuals with persistent hyperuricemia are more likely to develop T2D. The underlying mechanisms contributing to these associations may involve chronic systemic inflammation, oxidative stress, and endothelial dysfunction. They are almost identical in etiology, pathophysiology, complications, and management. Recent studies have revealed an intricate relationship between these two conditions, suggesting hyperuricemia may be equivalent to T2D. Screening for hyperuricemia at an early stage can prevent the development of prediabetes and later overt T2D. This review article aims to explore the concept of hyperuricemia as an equivalent of T2D and shed light on the transforming perception of this association.
Keywords: Uric acid, prehyperuricemia, hyperuricemia, type 2 diabetes, metabolic disorder, non-communicable disorder, endothelial dysfunction, systemic inflammation, oxidative stress, and preventive measures.
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