Year: 2024 | Month: April | Volume: 11 | Issue: 4 | Pages: 1-14
DOI: https://doi.org/10.52403/ijrr.20240401
Comparison of Characteristics and Clinical Outcomes of Children with Confirmed Tuberculosis and Unconfirmed Rapid Molecular Test Examination
Imil Irsal Imran1, Finny Fitry Yani2, Rusdi3, Yusri Dianne Jurnalis4, Rinang Mariko5, Rahmi Lestari6
1Department of Pediatric, Faculty of Medicine, Andalas University, Dr. M. Djamil General Hospital, Padang, West Sumatera, Indonesia
2Respirology Subdivision, Department of Pediatric, Faculty of Medicine, Andalas University, Indonesia
3Allergy and Immunology Subdivision, Department of Pediatric, Faculty of Medicine, Andalas University, Indonesia
4Gastrohepatology Subdivision, Department of Pediatric, Faculty of Medicine, Andalas University, Indonesia
5Infectious and Tropical Disease Subdivision, Department of Pediatric, Faculty of Medicine, Andalas University, Indonesia
6Neurology Subdivision, Department of Pediatric, Faculty of Medicine, Andalas University, Indonesia
Corresponding Author: Imil Irsal Imran
ABSTRACT
Background: Making a confirmation of TB diagnosis by bacteriological examination is difficult in children. Currently, the GeneXpert examination is better than AFB examination. However, obtaining a representative specimen is quite difficult in children cause some TB cases are established clinically.
Objective: To analyze the comparison of characteristics and clinical outcomes of children with confirmed tuberculosis by GeneXpert examination with clinical TB.
Method: A case-control study to evaluate the clinical characteristics and outcomes of TB patients aged 0-18 years who underwent GeneXpert examination at Dr. M Djamil Padang from July 2017 to June 2022.
Results: A total of 153 subjects consisted of 24% confirmed TB through GeneXpert examination and 76% were clinical TB. It was found clinical presentations more frequent in confirmed TB than clinical TB in complaints; fever and cough more than 2 weeks, malaise, contact history, did not have BCG immunization, lymph nodes enlargement, radiological features, and prolonged ESR, except for findings rales. Most subjects have recovered of chest X-ray in both groups.
Conclusion: Clinical presentations is more common in confirmed TB than clinical TB except for rales.
Keywords: TB, confirmed TB, clinical TB, clinical characteristic, clinical outcome.
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