Year: 2024 | Month: April | Volume: 11 | Issue: 4 | Pages: 215-223
DOI: https://doi.org/10.52403/ijrr.20240424
The Accuracy of Monocyte Lymphocyte Ratio as a Predictor of Mortality in Patients Undergoing Regular Haemodialysis at H Adam Malik General Hospital Medan
Aziz Rahman Muis1, Alwi Thamrin Nasution2, M. Feldi G. Nasution2
1Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
2Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Corresponding Author: Aziz Rahman Muis
ABSTRACT
Background: Chronic Kidney Disease (CKD) has become a world health problem with high morbidity and mortality rate. In CKD, chronic inflammation occurs, one of the causes including factors related to dialysis. Monocyte Lymphocyte Ratio (MLR) is a new haematology marker associated with tumour, inflammatory disease, and cardiovascular disease. MLR is also a predictor of infection complication in haemodialysis patients. The aim of this study is to assess the accuracy of MLR as a predictor of mortality in regular haemodialysis patients at H. Adam Malik General Hospital Medan
Method: This study is an analytic retrospective cohort study of CKD patients who undergoes regular haemodialysis, conducted in July-December 2023 at H. Adam Malik General Hospital Medan. Data were analysed using the SPSS program. Bivariate analysis was conducted to assess the correlation between the two variables. Then, ROC analysis was performed to assess the MLR as a mortality predictor.
Result: Total subject in this study was 60 regular haemodialysis patients with the majority of the subjects being male (88,3%), the mean age was 49,77± 13,09 years old and the mortality in this study was 16,7%. The median MLR value in this study was 0,345 (0,11-1,65). This study showed a significant relationship between MLR and mortality (p=0,003). MLR showed moderate performance to predict 30-days mortality in regular haemodialysis patients (AUC=74,4%).
Conclusion: MLR has moderate accuracy in predicting 30-day mortality in regular haemodialysis CKD patients.
Keywords: Monocyte Lymphocyte Ratio; MLR; Chronic Kidney Disease; CKD; Mortality.
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