Year: 2024 | Month: May | Volume: 11 | Issue: 5 | Pages: 579-593
DOI: https://doi.org/10.52403/ijrr.20240565
Revolutionizing Urolithiasis Management: A Paradigm Shift through Nutraceutical Interventions, Fluid Therapy and pH Maintenance - A Comprehensive Review
Arpita Nagaraj Shetty1, Karunakar Hegde2
1,2Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Mangalore- 574143, Karnataka, India
Corresponding Author: Arpita Nagaraj Shetty
ABSTRACT
Urolithiasis is characterized by the formation of mineral stones within the urinary tract, is a significant global health concern impacting millions worldwide. This review article examines the multifaceted nature of urolithiasis, encompassing its epidemiology, etiology, diagnosis, and management strategies. Key factors influencing stone formation include biochemical changes, dietary habits, hydration levels, genetic predispositions, and environmental factors. Diagnostic imaging methods such as ultrasonography and computed tomography aids in accurate diagnosis, while treatment options range from extracorporeal shock wave lithotripsy to dietary modifications and fluid therapy. Nutraceuticals, particularly phytoconstituents rich in polyphenols and alkaloids, offer promising avenues for managing urolithiasis by inhibiting crystal formation and supporting kidney function. Moreover, optimizing fluid intake and maintaining urinary pH levels play pivotal role in preventing stone recurrence. Prospects lie in the refinement of nutraceutical formulations, the integration of wearable technology for monitoring, and comprehensive clinical investigations to establish safety and efficacy. Ultimately, this review underscores the importance of holistic approaches to mitigating the burden of urolithiasis and improving patient outcomes.
Keywords: Extracorporeal Shock Wave Lithotripsy, Epidemiology, Fluid Therapy, Nutraceuticals, Urolithiasis.
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