Year: 2024 | Month: May | Volume: 11 | Issue: 5 | Pages: 625-627
DOI: https://doi.org/10.52403/ijrr.20240571
Disulfiram Induced Psychosis in Patients Seeking Over the Counter Treatment
Sambhu Prasad1, Saurabh Shekhar2, Sulagna Mallik3, Pankaj Kumarsup>4
1MBBS, MD, DM Associate Professor, Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), Patna, India
2MBBS, MD, Senior Resident, Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), Patna, India
3MBBS, Junior Resident, Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), Patna, India
4MBBS, MD, Additional Professor, Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), Patna, India
Corresponding Author: Dr. Sambhu Prasad, MBBS, MD, DM
ABSTRACT
Disulfiram is a deterrent in the management of alcohol use associated with neuropsychiatric manifestations, of which psychosis is common. The postulated mechanism is being its metabolite diethyldithiocarbamate being an inhibitor of dopamine beta-hydroxylase (DBH), an enzyme that catalyses the metabolism of dopamine (DA) to norepinephrine (NE) which results in an increase of DA concentrations in mesolimbic system resulting in psychosis. Other mechanisms are also postulated, like direct CNS toxicity, free radical damage. Here, are the two cases that were dependent to opioid given disulfiram surreptitiously land up with psychosis.
Keywords: Substance use disorders, Disulfiram, Psychosis, over the counter medicine
[PDF Full Text]