Year: 2024 | Month: June | Volume: 11 | Issue: 6 | Pages: 208-218
DOI: https://doi.org/10.52403/ijrr.20240624
Acute Dermal Toxicity of Liquid Smoke (Cocos nucifera L.) Grade 1
Hardiyanti Rukmana1, Masfria2,3, Emil Salim4
1Master in Pharmaceutical Sciences Program, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
3Nanomedicine Centre of Innovation, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
4Department of Pharmacology and Clinical/Community Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Corresponding Author: Masfria
ABSTRACT
Liquid smoke, a product from coconut shell waste, is a food preservative and antimicrobial substitute. It is produced through pyrolysis at 400-600°C, producing solid, liquid, and gas products. Toxicity studies need to be conducted to test the safety of medicinal products. This is because medicinal products that meet the requirements are those that have proven their efficacy and safety. Liquid smoke, especially grade 1, has not been studied further regarding its safety. This study aimed to determine the acute toxicity potential of grade 1 coconut shell liquid smoke. The experimental method involved collecting and processing samples, making liquid smoke, purifying them, and testing the effects of acute dermal toxicity. Results showed mild damage to liver and kidney organs, with microscopic liver tissue damage and kidney tissue damage.
Keywords: Cocos nucifera L., liquid smoke, toxicity, acute, subchronic
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