Year: 2024 | Month: August | Volume: 11 | Issue: 8 | Pages: 599-606
DOI: https://doi.org/10.52403/ijrr.20240864
Metanil Yellow Induces Oxidative Stress in Duodenal Visceral Smooth Muscle of Rat
Swarnali Biswas1, Sourapriya Mukherjee2, Goutam Paul1*
Department of Physiology, Kalyani University, Kalyani, India.
Corresponding Author: Goutam Paul
ABSTRACT
Metanil Yellow, a synthetic dye has huge application as a dye in the paint, textile, porcelain, and leather industries. Besides, it is widely used as a food colorant in the food industry because of its persistent yellow color despite of being categorised as non-permitted food color to attract customers. Consequently, eating food tainted with MY exposes humans to MY on a regular basis. Thus, the study was to examine any induction of oxidative stress on acute exposure of MY in the smooth muscles located at the wall structure of the duodenum, that with its contractile activity provides motility to it that performs the digestive and absorptive functions of the small intestine. From the results, we have found significant decrease in the activity of antioxidant enzymes- catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR); and increase in the levels of malondialdehyde (MDA) and lactate dehydrogenase (LDH) activity, biomarkers of oxidative stress in the duodenal visceral smooth muscles in a significant manner. In conclusion, MY significantly induces oxidative stress in smooth muscles found in the muscularis externa of the duodenal wall that provides the motility of the duodenum which is prerequisite for digestion and absorption of the food stuffs. The induction of oxidative stress in the dVSM might cause degenerative alterations that results in the impairment of its digestive and absorptive functions.
Keywords: Metanil yellow, duodenal visceral smooth muscle, oxidative stress, antioxidant enzymes, biomarkers of oxidative stress .
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