Year: 2024 | Month: September | Volume: 11 | Issue: 9 | Pages: 373-379
DOI: https://doi.org/10.52403/ijrr.20240940
Efficacy and Safety of Hyperimmunoglobulin Cytomegalovirus Therapy Against CMV Congenital Infections: A Systematic Review
Abitmer Gultom1,3, Jumaini Andriana Sihombing2, Karlos Berlusconi Sihaloho1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia
2Department of Histology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia
3General Hospital, Universitas Kristen Indonesia
Corresponding Author: Abitmer Gultom
ABSTRACT
Background: Cytomegalovirus infection in pregnancy can cause congenital CMV. CMV hyperimmunoglobulin therapy aims to prevent vertical infection to the fetus causing congenital CMV, therefore, the authors conducted a systematic literature review to determine the efficacy of hyperimmunoglobulin by reviewing outcome parameters. Methods: Systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta- Analysis (PRISMA) guidelines.
Results: Through data search in Pubmed, Science Direct, and Cochrane using the keywords 'Therapy' 'Pregnancy' 'Pregnant' 'Cytomegalovirus' and 'Treatment', 230 articles were obtained. Then the selection was carried out, 52 articles were excluded, 43 review articles, 30 case-control studies, 35 cohort studies, and 71 observational studies, so that 2 journals were obtained that met the inclusion criteria.
Conclusion: as much as 30% and 35.6% of CMV congenital events in the group of mothers given HIG, compared to the control group which was 44%.
Keywords: hyper immunoglobulin, cytomegalovirus, pregnancy, therapy
[PDF Full Text]