Year: 2025 | Month: October | Volume: 12 | Issue: 10 | Pages: 48-67
DOI: https://doi.org/10.52403/ijrr.20251007
A Study of Genetic Alterations in Triple-Negative Breast Cancer
Bhoomi Vaniya1, Dr. Nupur Patel2, Dr. Nidhi Gondaliya3, Dr. Trupti Trivedi4, Dr. Hemangini Vora5
1Ph.D. Scholar at Life Science department - Gujarat University, Junior Research Fellow -The Gujarat Cancer and Research Institute
2Research Assistant, The Gujarat Cancer and Research Institute
3Ph.D. co-guide, Assistant professor at Life Science department, Gujarat University
4Ph.D. guide, Assistant professor & Head Molecular Diagnostic and Research Lab 1, The Gujarat Cancer and Research Institute
5Professor & Head of the department - Cancer Biology, The Gujarat Cancer and Research Institute
Corresponding Author: Dr. Trupti Trivedi
ABSTRACT
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subtype of breast cancer lacking estrogen receptor, progesterone receptor, and HER2 expression. This limits the effectiveness of targeted hormonal therapies and contributes to poor clinical outcomes. Recent advances in next-generation sequencing (NGS) have significantly enhanced our understanding of the complex genomic, transcriptomic, epigenomic, and metabolomic landscape of TNBC. This review discusses the molecular subtypes of TNBC, chromosomal abnormalities, copy number variations, transcriptomic signatures, epigenetic modifications and emerging metabolomic markers that offer promise in early detection, prognosis, and treatment resistance. The integration of multi-omics data underscores the biological complexity of TNBC and offers new avenues for precision medicine.
Keywords: Triple-negative breast cancer, Genetic alterations, Epigenomics, Transcriptomics, Metabolomics, Precision medicine
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