Year: 2025 | Month: December | Volume: 12 | Issue: 12 | Pages: 156-158
DOI: https://doi.org/10.52403/ijrr.20251217
Melatonin Supplementation in Beta-Blocker -Induced Insomnia: A Literature Review
Kirtick Poovendran, Vishnupriya Krishnaveni, Pavana Chandran, Mohammad Ibrahim Hashmi
International Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia
Corresponding Author: Kirtick Poovendran
ABSTRACT
Beta-blockers, widely prescribed for cardiovascular diseases, have been linked to sleep disturbances, notably insomnia and vivid dreaming. This effect is primarily attributed to the suppression of endogenous melatonin secretion via β1-adrenergic receptor blockade in the pineal gland [2]. Melatonin, a neurohormone produced by the pineal gland, regulates the circadian rhythm and promotes sleep onset. This review summarizes the available evidence On the relationship between beta-blocker therapy and melatonin suppression, and evaluates the therapeutic potential of melatonin supplementation in mitigating insomnia among these patients.
Keywords: beta-blockers, insomnia, melatonin, pineal gland, sleep disturbance, circadian rhythm, cardiovascular disease.
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