Year: 2025 | Month: January | Volume: 12 | Issue: 1 | Pages: 16-21
DOI: https://doi.org/10.52403/ijrr.20250104
High Serum S100B Protein Levels as A Risk Factor for Impaired Cognitive Function in Acute Non- Hemorrhagic Stroke: A Literature Review
Anak Agung Derisna Citra Saraswati1, Anak Agung Ayu Putri Laksmidewi2, Anak Agung Ayu Meidiary2
1,2 Neurology Department, Faculty of Medicine, Udayana University / Prof. Dr. I.G.N.G Ngoerah General Hospital, Bali Indonesia
Corresponding Author: Anak Agung Derisna Citra Saraswati
ABSTRACT
The incidence of acute non-hemorrhagic stroke disease has a high disability rate and mortality rate and is a serious threat to people’s health and life and can burden families and society. The development of stroke after the onset of acute stroke, especially acute non-hemorrhagic stroke is not uncommon and has become a popular research topic in recent years. Various mechanism can occur, one of which is neuroinflammation. Stroke often leads to lifelong disability, including motor impairment, cognitive impairment, language impairment, and psychological impairment. Serum S100B is a calcium-binding protein that can determine disease severity and predict clinical outcomes to monitor disease progression and response to treatment. It was reported that serum S100B protein levels were detected to be higher in patients with cognitive impairment compared to normal ones.
Keywords: Serum S100B protein, cognitive impairment, non-hemorrhagic stroke
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