Year: 2025 | Month: January | Volume: 12 | Issue: 1 | Pages: 297-303
DOI: https://doi.org/10.52403/ijrr.20250138
An Overview of LDH, Calcium, and CRP Levels in Bone Metastasis Due to Primary Cancer: Breast, Lung, Thyroid, Prostate, and Liver Cancer at Prof. Dr. I.G.N.G. Ngoerah Hospital in January-March 2024
Anastasia Gwyneth Roselyn1, I Wayan Subawa2, I Gede Eka Wiratnaya2, I Ketut Suyasa2
1Undergraduate Medical Study Program, Faculty of Medicine, Udayana University
2Department of Orthopedic, Faculty of Medicine, Udayana University
Corresponding Author: I Wayan Subawa
ABSTRACT
Background: Bone metastasis is a disease that occurs when cancer cells began to spread from their original site to bone tissue. These cancer cells are able to reach bones due to osteomimicry, the ability to express genetic profiles that resemble the target location of metastasis.The most common primary cancers that cause bone metastases included lung cancer, breast cancer, and prostate cancer. Based on previous research, some factors that may influenced the likelihood of bone metastasis are such as: LDH, calcium, and CRP levels.
Method: The purpose of this study is to give an overview of the distribution of LDH levels, calcium levels and CRP levels in bone metastasis due to primary cancer: breast, lung, thyroid, prostate, and liver cancer at Prof. Dr. I.G.N.G Ngoerah General Hospital in January-March 2024. This study used a quantitative descriptive epidemiological study with a cross-sectional design. The study's dependent variable was bone metastasis, while the independent variable were primary cancer of: breast, lung, thyroid, prostate, and liver cancer, LDH level, calcium level, and CRP level. A total of 53 medical records were taken out of 186 patients with bone metastasis. The research lasted for 3 months, starting in January 2024 and ending in March 2024.
Results: This research found an abnormality in LDH and CRP levels on bone metastasis due to breast cancer; abnormality in LDH, calcium, and CRP levels on bone metastasis due to lung cancer abnormality in CRP levels on bone metastasis due to thyroid cancer; abnormality in LDH levels on bone metastasis due to prostate cancer; and abnormality in LDH and calcium levels on bone metastasis due to liver cancer.
Conclusion: In this study, it can be concluded that there are mostly abnormalities in LDH and CRP, but mostly normal calcium levels in patients with bone metastasis due to primary cancer: breast, lung, thyroid, prostate, and liver cancer at Prof. Dr. I.G.N.G Ngoerah General Hospital in January-March 2024.
Keywords: Bone metastasis, LDH, calcium, CRP, breast cancer, lung cancer, thyroid cancer, prostate cancer, and liver cancer
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