Year: 2025 | Month: February | Volume: 12 | Issue: 2 | Pages: 251-264
DOI: https://doi.org/10.52403/ijrr.20250229
Salivary Biomarkers in Oral Squamous Cell Carcinoma Diagnosis and Prognosis - A Review
Nunisa Phairingdao1, Chandra, Deka, Akshay1, Srinivasan, Vidhya2
1Department of Medical Laboratory Technology, Regional College of Health Sciences, Guwahati, Assam, India.
2Department of Medical Laboratory Technology, Girijananda Chowdhury University, Guwahati, Assam, India.
Corresponding Author: Vidhya Srinivasan
ABSTRACT
Objectives: The purpose of this study is to investigate the increasing prevalence and consequences of oral cancer, a leading cause of cancer-related deaths worldwide. To explore the role of salivary biomarkers, in the diagnosis and progression of oral squamous cell carcinoma. To emphasize the potential of salivary biomarkers for advancing diagnostic methods and improving treatment options for oral cancer.
Materials and Methods: A comprehensive review of the existing literature was conducted using databases such as Google Scholar and PubMed. Search terms included “Salivary Biomarkers,” “Oral Squamous Cell Carcinoma,” “Head and Neck Squamous Cell Carcinoma,” and “Adiponectin.” Articles were filtered based on parameters such as tumor location, relevance to the study, and study region.
Results: Emerging salivary biomarkers, such as cytokines, show potential in diagnosing oral squamous cell carcinoma. Adiponectin, an adipokine with anti-inflammatory and metabolic properties, was highlighted as a key regulator of the inflammatory environment and tumor progression in oral cancer.
Conclusions: Salivary biomarkers, particularly cytokines and adiponectin, hold promise as non-invasive tools for the early detection and diagnosis of oral squamous cell carcinoma. Large-scale clinical trials are necessary to solidify the utility of adiponectin and other salivary biomarkers in personalized diagnostic and treatment strategies.
Keywords: Adiponectin, Adipokines, Biomarkers, Tumor.
[PDF Full Text]