Year: 2025 | Month: June | Volume: 12 | Issue: 6 | Pages: 628-634
DOI: https://doi.org/10.52403/ijrr.20250671
Effectiveness of Combination Therapy of Bone Marrow-Derived Mesenchymal Stem Cell for Enhancing Potential Therapeutic Effect on Ankle Arthritis: A Systematic Review
I Komang Gede Satria Mulyana Nugraha1, I Gusti Lanang Agung Wiradinata2, Ida Bagus Anom Krishna Caitanya3
1General Practitioner, Bali Royal Hospital, Bali, Indonesia
2General Practitioner, Sanjiwani Hospital, Bali, Indonesia
3Department of Orthopaedic and Traumatology, Bali Royal Hospital, Bali, Indonesia
Corresponding Author: I Komang Gede Satria Mulyana Nugraha
ABSTRACT
Background and Objectives: Current treatment options for ankle arthritis often provide only short-term therapeutic benefits, with frequent recurrence of symptoms. In recent years, various stem cell based therapies have been developed due to their regenerative potential and ability to promote tissue repair in ankle arthritis. Bone marrow-derived mesenchymal stem cells (BM-MSCs) represent one such therapeutic approach, isolated from bone marrow and expanded in vitro, offering notable anti-inflammatory and osteoregenerative properties. The combination of BM-MSC therapy with existing treatment modalities is anticipated to enhance overall therapeutic efficacy.
Methods: This systematic review aims to evaluate the potential therapeutic effects of combining bone marrow-derived mesenchymal stem cell (BM-MSC) with existing treatment modalities. Comprehensive literature search was conducted using databases including PubMed, ResearchGate, Google Scholar, and ScienceDirect. Eligible studies included animal models, interventional and descriptive research, as well as other analytical and observational study designs.
Results: Five studies met the eligibility criteria and were included in the review. These studies utilized BM-MSC that had been isolated and cultured from bone marrow tissue. The experimental models involved rats in which arthritis had been experimentally induced. Overall, the combination of BM-MSCs with various therapeutic interventions demonstrated enhanced therapeutic effects on ankle arthritis, as evidenced by both pathological and radiological improvements. Additional benefits included augmented anti-inflammatory, antioxidant, and anti-arthritic properties.
Conclusion: The findings indicated that the combination of bone marrow-derived mesenchymal stem cells (BM-MSCs) effectively promotes tissue repair and delays joint degradation in ankle arthritis. The overall conclusion suggests that integrating BM-MSC therapy with existing treatment modalities may enhance therapeutic efficacy. However, additional research is warranted, particularly in human clinical trials, to address current limitations and to determine the optimal dosage, therapeutic safety, and potential side effects associated with each combination therapy.
Keywords: Ankle arthritis; Stem cell; Bone marrow; Mesenchymal; Therapeutic effect
[PDF Full Text]