Year: 2025 | Month: July | Volume: 12 | Issue: 7 | Pages: 1-9
DOI: https://doi.org/10.52403/ijrr.20250701
The Effect of Combined Platelet-Rich Plasma and Bone Graft for Bone Regeneration: A Systematic Review
Leonardus William Kuswara1, Putu Astawa2, Cokorda Gde Oka Dharmayuda2
1Resident, Dept. Orthopaedic & Traumatology, Prof IGNG Ngoerah General Hospital, Udayana University, Bali, Indonesia
2Orthopaedic Surgeon, Dept. Orthopaedic & Traumatology, Prof IGNG Ngoerah General Hospital, Udayana University, Bali, Indonesia
Corresponding Author: Leonardus William Kuswara
ABSTRACT
Introduction: Bone regeneration is a critical focus in orthopedic surgery, especially for challenging cases such as non-union fractures and large bone defects. Emerging treatments that combine platelet-rich plasma (PRP) with bone grafts (BG) have shown potential to enhance bone regeneration, reduce pain, and improve functional outcomes. This systematic review aims to evaluate the effect of PRP combined with BG on bone healing outcomes compared to standard treatments.
Methods: This review was conducted following the PRISMA guidelines, we explored published articles that experimented on the use of PRP combined with BG in treating any kind of bone injury from several databases encompassing PubMed, ScienceDirect, and grey literature (Google Scholar) for the last ten years. The authors name, year of publication, origin country, study design, sample size, PICO (population, intervention, control, and outcome) criteria and studies outcome will be extracted from the selected studies.
Result: Our systematic review identified seven studies encompassing a total of 455 samples from various countries. Functional scores, including the Harris Hip Score (HHS) in five studies, were consistently higher in PRP groups. Furthermore, VAS scores were significantly lower in the PRP groups compared to the control at the final follow up duration. Additionally, healing and union rates were notably higher in three studies compared to the control group. PRP groups also demonstrated shorter healing durations compared to the control group in three studies. Finally, the complication rates were notably higher in control group than PRP group.
Conclusion: PRP combined with BG enhances bone healing outcomes, reducing pain and recovery time and promoting functional improvement, thereby offering a promising approach for treating complex bone injuries.
Keywords: bone graft, bone regeneration, necrosis of the femoral head, non-union, platelet-rich plasma.
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