Year: 2025 | Month: August | Volume: 12 | Issue: 8 | Pages: 439-444
DOI: https://doi.org/10.52403/ijrr.20250852
Exploring the Relationship Between HbA1c and Lipid Profile Parameters in Type 2 Diabetes Mellitus: Evidence from Indonesian Community-Based Chronic Disease Program
SM Rezvi1,2, Mutia Lailani2,3, Radhia Ashabul Kafi Bey4, Nur Afrainin Syah5
1Department of Microbiology, 2Center for Diagnostic and Research on Infectious Diseases (PDRPI), 3Department of Physiology, 4Emergency Medical Department Rasidin Regional Public Hospital, 5Department of Anatomy Faculty of Medicine,
Universitas Andalas, Padang, Indonesia
Corresponding Author: SM Rezvi
ABSTRACT
Type 2 diabetes mellitus (T2DM) is a global health issue linked to insulin resistance and lifestyle factors. In Indonesia, it has prompted the Chronic Disease Management Program (Prolanis) to monitor glycemic control (HbA1c) and lipid levels, addressing the risk of cardiovascular complications. Our objective was to evaluate the correlation between glycemic control and lipid profiles in patients with T2DM enrolled in the Prolanis program. We carried out a retrospective analysis of secondary data derived from laboratory results of patients diagnosed with T2DM and enrolled in the Prolanis program 2024 in Padang, Indonesia. The data collected comprised HbA1c levels and lipid profiles. We categorized the HbA1c levels into two groups: non-diabetic and diabetic. Furthermore, we classified the components of the lipid profile as follows: total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. A correlation analysis was conducted to examine the relationship between HbA1c levels and each lipid profile component using the chi-square test in STATA Ver.16. A total of 17 patients (60.76 ± 7.25 years) with type 2 diabetes enrolled in the Prolanis program in 2024 were analyzed for their HbA1c and lipid profiles. Chi-square analysis showed no significant associations between HbA1c levels and any lipid profile component, including total cholesterol (p = 0.909, OR = 1.125), HDL (all patients were normal), LDL (p = 0.778, OR = 0.75), and triglycerides (p = 0.767, OR = 1.5). This study highlighted the need for continued investigation into the complex factors influencing lipid profiles in type 2 diabetes, as no significant relationship was found between glycemic control and lipid abnormalities in this study.
Keywords: cardiovascular risk, dyslipidemia, high-density lipoprotein, low-density lipoprotein, non-insulin-dependent diabetes mellitus, total cholesterol, triglycerides
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