Year: 2026 | Month: March | Volume: 13 | Issue: 3 | Pages: 168-175
DOI: https://doi.org/10.52403/ijrr.20260320
Tranexamic Application on Open Procedure of Shoulder: Systematic Review and Meta-Analysis of Randomized Study
Pande Putu Agung Wilia Kesawa Putra1, Anak Agung Gde Yuda Asmara2
1Researcher. PhD in Biochemistry, Mritwika Apartment, P30 Gabtala Lane, West Bengal,
Kolkata-700 060.
2Assistant Professor, Department of General Medicine, College of medicine & JNM Hospital, Kalyani, Nadia, West Bengal, India, Pin code- 741235.
3Assistant Teacher, Birla Bharati, Taratolla, Santoshpore New Road, Near Nature Park, P.O.- Bidhangarh, West Bengal, Kolkata- 700 066.
Corresponding Author: Pande Putu Agung Wilia Kesawa Putra
ABSTRACT
Background: Open shoulder procedures are frequently associated with significant intraoperative blood loss and postoperative hemarthrosis, which may impair surgical visualization, increase transfusion needs, and delay recovery. Tranexamic acid (TXA) has demonstrated efficacy in reducing perioperative bleeding in major orthopedic surgeries, especially hip and knee arthroplasty, but open shoulder surgery data is lacking. This research examines the effects of TXA in open shoulder surgery using recent studies.
Materials and Methods: A comprehensive review and meta-analysis of randomized controlled trials compared TXA vs non-TXA results. A systematic search of PubMed, MEDLINE, EMBASE, and CENTRAL found relevant papers.
Results: TXA substantially decreased postoperative drain output compared to placebo (MD –61.31 mL, 95% CI –93.00 to –28.72; p = 0.0002). Compared to placebo, TXA substantially decreased perioperative hemoglobin decline (MD –0.90, 95% CI –1.35 to –0.44; p = 0.0001) and considerably reduced postoperative hematoma risk (OR 0.21, 95% CI 0.09 to 0.45; p < 0.0001). Although TXA reduced total blood loss, operational time, and postoperative VAS, these changes were not statistically significant.
Conclusion: TXA reduces intraoperative blood loss during shoulder surgery without serious consequences
Keywords: randomized controlled trials, shoulder surgery, tranexamic acid
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