Original Research Article
Year: 2016 | Month: June | Volume: 3 | Issue: 6 | Pages: 68-75
Prevalence of HPV Infection in Women at a Tertiary Care Hospital in Mumbai
Preeti U. Deshpand1*, Preeti R. Mehta,2*, Shilpa C. Kerkar3**, Purva P. Sarkate4*, Nayana A. Ingole5*, Jayanti Mania-Pramanik6**, Padmaja Samant-Mavani5#, Urmila Parikh7#
1Speciality Medical Officer, 2Professor & Head, 3Technician C, 4Assistant Professor, 5Associate Professor, 6Scientist F, 7Senior Scientific Officer,
*Department of Microbiology, Seth G.S Medical College and KEM Hospital, Mumbai.
**National Institute for Research in Reproductive Health, Mumbai.
#Department of Obstetrics and Gynaecology, Seth G.S Medical College and KEM Hospital, Mumbai.
Corresponding Author: Preeti U. Deshpande
ABSTRACT
Background: Prevalence of Human Papilloma Virus (HPV), a known cause of cervical cancer has been reported to be more in HIV positive women. However, the HPV prevalence data in general population and HIV positive women in India is scarce. This hinders the development of policies regarding the screening, vaccination and follow- up of women for HPV infection
Aims: To estimate the prevalence of HPV in adult women and compare HPV prevalence in HIV infected and HIV non- infected women.
Methods: Women attending Gynaecology OPD with known HIV status were enrolled in this cross- sectional study. Their cervical specimens were collected for HPV DNA PCR and genotyping (HPV types 6, 11, 16 and 18). Statistical analysis was done using Chi- square/ Fisher’s exact test.
Results: A total of 188 women were enrolled of which 38 were HIV positive and 150 were HIV negative. Of the total cervical specimens collected, 172 showed adequate DNA and HPV DNA PCR were positive in 15 of these samples (8.72%). HPV DNA positivity was 13.89% (5/36) in HIV infected and 7.35% (10/136) in HIV non- infected women (P=0.3147). High risk HPV genotypes 16/18 were found in 12/15 (80%) women.
Conclusions: Owing to the 8.72% prevalence of HPV, there is a need to screen all adult women for early detection of HPV infection and HPV vaccination should also be considered.
Key words: HPV, HIV, cervical cancer, screening, vaccination.