Original Research Article
Year: 2018 | Month: October | Volume: 5 | Issue: 10 | Pages: 108-111
>Free Triiodothyronine as a Novel Acute Phase Reactant in Acute Myocardial Infarction
Dr. Sanghamitra Chakraborty1, Dr. Soma Gupta2, Pinki Bera3
1Demonstrator in the Department of Biochemistry, Nil RatanSircar Medical College, Kolkata, West Bengal
2Professor &Head, Department of Biochemistry, NRS Medical College, Kolkata, West Bengal
3Trainee in Department of Biotechnology, Bengal Institute of Technology, West Bengal
Corresponding Author: Dr. Sanghamitra Chakraborty
ABSTRACT
The burden of both cardiovascular mortality and morbidity has escalated in recent time. Atherosclerosis initiates the events of cardiovascular diseases. Inflammation initiates atherosclerosis whereas myocardial infarction is the end point of the atherosclerosis trajectory. Free triiodothyronine, the unbound portion, is used traditionally as thyroid function test analyte. Literature reviews suggests an immense role of free triiodothyronine as an inflammatory marker in pathogenesis of atherosclerosis and chronic kidney disease. The purpose of this observation study was to determine the serum concentration of free T3 in patients suffering from myocardial infarction and evaluate its association with C-reactive protein (CRP) and compare with healthy subjects. The study participants were evaluated with ECG and Echocardiography for cardiac changes. The data was calculated and compared using IBM SPSS software. The serum concentration of free T3 was significantly lower in cases (p=0.02). In this instance, it was observed that free T3 may be associated with inflammation of cardiovascular disease.
Key words: Atherosclerosis, triiodothyronine, C-reactive protein
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