Original Research Article
Year: 2018 | Month: November | Volume: 5 | Issue: 11 | Pages: 104-110
Clinico-Etiological Profile of Bacterial Infections in Children with Sickle Cell Anemia
Dr. Dipak Madavi1, Dr. Bharath Kumar S2, Dr. Pritesh T. Khatwar3
1Associate Professor, 2Junior Resident, 3Assistant Professor,
Dept of Paediatrics, IGGMC, Nagpur 440018.
Corresponding Author: Dr. Dipak Madavi
ABSTRACT
Objective: In sickle cell anemia, fever is a common presenting symptom and is frequently the first indication of serious and life-threatening bacterial infection. There is a lack of study in central India, which has high prevalence of sickle cell anemia, showing causes of fever in them. So we studied various causes of fever and bacteremia in patients with sickle cell anemia and to provide data which will help to reduce morbidity and mortality by early intervention in patients of sickle cell disease.
Methods: This was a cross sectional observational study which contains 163 patients of sickle cell anemia (SS) presenting with fever in the age group between 6 months to 12 years. All cases were investigated with CBC, blood culture, urine examination, chest X-ray and other investigations as indicated.
Result: Amongst 163 cases enrolled, most common system to involve was respiratory system (44%), followed by gastrointestinal system (24%) and genitourinary system (8%). In these cases pneumonia was the most common clinical diagnosis (23%). Streptococcus pneumoniae along with the, Klebsiella pneumoniae and E. coli were found to be the common pathogens causing a febrile illness in sickle cell anaemia. Gram negative bacteria were responsible for 56. 25% of bacteremia.
Conclusion: We concluded that, the respiratory system was the most common one to get involved in patients of sickle cell anaemia presenting with fever and pneumonia was the most common diagnosis in it. Streptococcal pneumoniae along with Klebsiella pneumoniae and E. coli were found to be the common pathogens causing a febrile illness and bacteremia in patients of sickle cell anemia.
Key words: Sickle cell anemia, Fever, Bacteremia.
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