Original Research Article
Year: 2018 | Month: November | Volume: 5 | Issue: 11 | Pages: 154-162
A Study of Correlation of Perceived Stress with Serum Prolactin Levels in Newly Diagnosed Cases of Hypothyroidism in Females in an Urban Population of a Developing Country
Dr. Arunima Chaudhuri1, Dr. Samarjit Koner2
1Associate Professor Department of Physiology, Rampurhat Government Medical College and Hospital (Affiliated to West Bengal University of Health Sciences), Rampurhat, West Bengal, India.
2Demonstrator, Department of Biochemistry, College of Medicine and Sagore Dutta Hospital (Affiliated to West Bengal University of Health Sciences), Kamarhati, West Bengal, India.
Corresponding Author: Dr. Samarjit Koner
ABSTRACT
Background: Prolactin affects the brain and mood but, on the other hand, personality traits and environmental factors may stimulate the secretion of prolactin and may play a role in the genesis of the disease.
Aims: To study correlation of Prolactin levels and Perceived stress scores in newly diagnosed hypothyroid females and subjects with clinical and subclinical hypothyroidism Materials and methods:
Materials and methods: This pilot study was conducted in Burdwan Medical College on two hundred and sixty newly diagnosed female hypothyroid subjects in a period of 12 months after taking institutional ethical clearance and informed consent of the subjects. Anthropometric Measurements -Height, Weigh, Body mass index (BMI), Presumptive stressful Life Event Stress Scale (PSLES) scores, Perceived stress scale(PSS) scores, TSH, fT4, serum prolactin levels. Subjects were divided into two groups: Hypothyroid individuals and subjects with subclinical Hypothyroidism. The computer software “Statistical Package for the Social Sciences (SPSS) version 16 (SPSS Inc. Released 2007. SPSS for Windows, Version 16.0. Chicago, SPSS Inc.)” was used to analyze the data.
Results: 260 newly diagnosed hypothyroid females were enrolled in our study. Among these 130 were clinical hypothyroid and 130 were subclinical hypothyroid patients. There was no difference in socioeconomic status, dietary habits, educational status, age between the two groups. 126 subjects in the subclinical hypothyroid group were married and 128 in the hypothyroid group. Significant difference was found between clinical and subclinical hypothyroid females for mean BMI(p=0.002), mean TSH(p<0.0001), mean fT4(p<0.0001), mean PRL(p=0.002), mean PSLES(p<0.0001), mean PSS(p<0.0001) (Table1).TSH values, PRL were positively correlated with PSS values while ft4 values were negatively correlated with PSS values in both clinical and subclinical hypothyroid subjects.
Conclusions: Hypothyroid female individuals may have hyperprolactinemia and perceived stress may be a significant contributor to this problem.
Key words: Prolactin, stress, hypothyroidism.
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