Original Research Article
Year: 2018 | Month: December | Volume: 5 | Issue: 12 | Pages: 188-192
Pre-Emptive Analgesic and Opioid Sparing Effect of Ketamine in Patients Undergoing Total Radical Mastectomy
Rajender Kumar1, Shakti Datt Sharma2
1DA, DNB (Anaesth), Sr. Specialist, Department of Anesthesia & Intensive Care, Dr. BSA Medical College & Hospital, New Delhi, India
2MD, CMO (SAG), Department of Anesthesia & Intensive Care, Dr BSA Medical College & Hospital, New Delhi, India
Corresponding Author: Shakti Datt Sharma
ABSTRACT
Background: The present study has been undertaken to evaluate pre-emptive analgesic and opioid sparing effect of intravenous ketamine in patients undergoing total radical mastectomy.
Method: Eighty female patients undergoing breast cancer surgery under general anesthesia, in a double-blinded, placebo controlled study were randomly divided into two groups of 40 patients each. Group K received ketamine 0.3mg/kg IV just before induction. Group C received normal saline as placebo.
Result: Time to first analgesic dose (TFA) required was significantly delayed in ketamine as compared to placebo group. Statistically significant difference was seen in Visual analog score (VAS), Prince Henry score (PHS) and mean morphine consumption between ketamine and control group.
Conclusion: This study proved that ketamine has a definitive role in reducing postoperative pain and has opioid sparing effect in patients undergoing modified radical mastectomy.
Key words: Pre-emptive analgesia, Ketamine, Post-operative pain
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