Original Research Article
Year: 2018 | Month: December | Volume: 5 | Issue: 12 | Pages: 406-416
Comparative Evaluation of Short Course Chemotherapy of Patients of Pulmonary Tuberculosis with and Without Diabetes Mellitus
Nitin Tangri1, Sameer Singhal2, Prachi Singhal3, Priyanka Tangri4
1Assistant Professor, Department of Respiratory Medicine, Dr. Radhakrishnan Govt. Medical College, Hamirpur, Himachal Pradesh.
2Professor, Department of Respiratory Medicine, M.M.Institute of Medical Sciences & Research, Mullana, Ambala, Haryana.
3Reader, Department of Prosthodontics, M.M. College of Dental Sciences & Research, Mullana, Ambala, Haryana.
4Associate Professor, Department of Biochemistry, Dr. Radhakrishnan Govt. Medical College, Hamirpur, Himachal Pradesh.
Corresponding Author: Priyanka Tangri
ABSTRACT
Tuberculosis (TB) remains a major cause of mortality in developing countries and in these countries, diabetes prevalence is increasing rapidly. The rising prevalence of diabetes mellitus in TB-endemic areas may adversely affect TB control. Patients co-affected with both diabetes mellitus (DM) and tuberculosis even have higher rates of treatment failure and death. Given the public health implications of a causal link between diabetes mellitus and tuberculosis, there is a clear need for a systematic assessment of association in the medical literature. The present case-control study was designed to evaluate the clinicoradiological profile and the response of short course chemotherapy in a total of 100 patients of pulmonary tuberculosis (PTB) with and without diabetes mellitus attending the OPD and wards of Department of Respiratory Medicine, MMIMSR, Mullana, Ambala. The results of the study indicated that the patients with TB and diabetes mellitus are older, more likely to have hemoptysis and pulmonary cavitations, be smear positive at diagnosis and remain positive at the end of 1st and 2nd month of treatment. On chest X-ray, pulmonary tuberculosis patients with diabetes mellitus (PTB-DM) had a higher prevalence of cavitary lesion(s) but no statistical significant difference was found between two groups. However, PTB-DM cases may be considered more contagious due to higher prevalence of cavitary lesions compared to those without diabetes mellitus. In conclusion, it has become imperative to use the knowledge available for active case finding, treatment of latent TB and for diagnosis, detection and treatment of diabetes mellitus, thus controlling the global merging epidemics of TB and DM.
Key words: Pulmonary tuberculosis, Diabetes mellitus, Clinicoradiological profile, short course chemotherapy.
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