Original Research Article
Year: 2018 | Month: January | Volume: 5 | Issue: 1 | Pages: 72-79
Effects of Tomato Extract (Lycopersicon Esculentum) on Carbimazole-Induced Alterations in Kidney of Albino Rats
Uchendu Ikenna Kingsley
Division of Clinical Chemistry, Department of Medical Laboratory Science, University of Nigeria, Enugu Campus, Nigeria
ABSTRACT
Acute Kidney Injury has a very high mortality and morbidity despite advances in clinical treatment. The health benefits of tomato extract on kidney injury has not been extensively studied. This research investigated the effects of tomato extracts on carbimazole-induced alterations in the kidney of albino rats. A total of 24 albino rats weighing (100±25g) were randomly divided into four groups (A-D) with six rats per group. Group A served as normal control and received no treatment. Group B received only Carbimazole (60mg/kg, oral) daily for 3 weeks and served as negative control. Group C received Vitamin C (200mg/kg, oral) in the presence of carbimazole challenge and served as the positive control and Group D which served as the test group received Tomato extract (30mg/kg, oral) in the presence of Carbimazole challenge. The Carbimazole administration resulted in Kidney injury with Serum Creatinine, Urea and Potassium levels: 1.57±0.12mg/dl; 47.00±1.00 mg/dl and 6.43±0.54mmol/l respectively. The administration of Tomato extracts resulted in the amelioration of the Carbimazole-induced kidney damage with Serum Creatinine, Urea and Potassium levels: 0.83±0.20mg/dl (P˂0.05); 25.67±3.38mg/dl (P˂0.01) and 4.77±0.12mmol/l (P<0.05) respectively. Histopathological results also revealed no significant kidney degeneration in the Tomato group; hence the kidneys were protected by the Tomato extract. The phytochemicals present in the Tomato extracts may have protected the kidneys from carbimazole-induced kidney injury. Intake of Tomato extract protects the kidneys from acute Kidney Injury.
Key words: ethnopharmacology, renoprotection, nephrototoxicity, Lycopersicon esculentum, carbimazole.
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