Original Research Article
Year: 2018 | Month: February | Volume: 5 | Issue: 2 | Pages: 8-15
Anti-Hepatotoxic Effect of Soy (Glycine Max) Against Tetra Chloromethane (CCL4)-Induced Liver Damage in Albino Rat
Ikenna Kingsley Uchendu
Division of Clinical Chemistry, Department of Medical Laboratory Science, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
ABSTRACT
Many liver injuries have been linked to drugs or alcohol. The hepatoprotective potential in Soy bean has remained understudied over the years. The aim of this study was to investigate the anti-hepatotoxic effect of Glycine max against tetra chloromethane (CCl4)-induced liver damage in rats. Phytochemical tests were performed. A total of 24 male albino rats weighing(100±25g) were randomly divided into four groups (I−IV) with six rats per group. Group IV served as normal control and received no treatment. Group III received only CCl4 (1ml/kg b. wt., 1:1v/v mixture of CCl4 and liquid paraffin, i.p) and served as negative control. Group II received Vitamin C (200mg/kg b.wt, oral) and served as the positive control and Group I which served as test group received Soymilk (2000mg/kg, oral) in the presence of CCl4challenge for 4 weeks.CCl4 administration to the rats resulted in liver damage with AST, ALT and ALP levels: 162.00±2.000 IU/L; 93.330±2.404 IU/L and 508.333±30.046 IU/L respectively. The daily administration of Soymilk resulted in the mitigation of the CCl4-induced liver damage with AST, ALT and ALP levels: 121.667±4.410 IU/L (P˂0.01); 77.333±1.453 IU/L (P˂0.01) and 456.333±22.048 IU/L (P>0.05) respectively. Histopathological result also revealed minor or no significant hepatocellular degeneration in soy group; hence hepatoprotection by Glycine max. Glycine max possesses liver protective properties against CCl4- induced liver damage.
Key words: ethnopharmacology, hepatoprotection, hepatotoxicity, liver, soybean, tetrachloromethane
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