Original Research Article
Year: 2018 | Month: April | Volume: 5 | Issue: 4 | Pages: 1-5
Should Clinician Suspect Hormonal Disturbances at Early Stages of HIV Infection in Males?- A North Indian Study
Dr. Asha Kumari1, Dr. Deepika Dalal2, Dr. Rajesh Kumar3, Dr. Shashi Seth4, Dr. Veena Ghalaut5, Dr. Gulshan Prakash6
1Assistant Professor, Department of Biochemistry, SHKM, GMC, Nalhar, Nuh
2Demonstrator, 3Postgraduate Student, 4Retired Professor, 5Sr. Prof & Head,
Department of Biochemistry, PGIMS, Rohtak
6Medical Officer, General Hospital, Mandikhera, Mewat, Haryana, India
Corresponding Author: Dr. Asha Kumari
ABSTRACT
Despite decades of research, HIV seropositive subjects continue to suffer from myriad complications. Endocrinopathies is one area which has emerged after the advent of HAART for HIV infection. As the life span of these patients has increased and number of HIV positive children is increasing, hormonal imbalances continues to affect patient management. This study was planned to assess whether reproductive hormonal disturbances are present in HAART naive HIV seropositive male subjects attending ART center, PGIMS, Rohtak. A correlation between Hormone levels- Testosterone, Estrogen and Progesterone with CD4+ cell counts was also studied. Fifty three cases were compared with fifty three healthy age matched controls. Cases were segregated into three groups depending upon CD4 cell counts as: Group A-CD4 cell counts < 200/mm3, Group B-CD4 cell counts 200-350/mm3, Group C-CD4 cell counts > 350/mm3. Controls were placed in Group 4.Mean testosterone level was significantly decreased in male cases in all groups than controls. Significant decrease in testosterone levels in males was seen in comparison between Group 1 vs 4, Group 2 vs 4 , Group 3 vs 4.Estrogen levels were not decreased non-significantly between cases and controls. 78.9% males in group A and 72.2% in group B had Progesterone levels <0.28 ng/ml as compared to 12.5% in group C and 7.5% in controls (p<0.001). Conclusion: reproductive hormones should be assessed in HIV positive males on disease detection for better management.
Key words: HIV, endocrinopathy, testosterone, estrogen, progesterone, AIDS, hypogonadism.
[PDF Full Text]