Original Research Article
Year: 2018 | Month: May | Volume: 5 | Issue: 5 | Pages: 95-101
Microalbuminuria: An Early Indicator of Kidney Dysfunction in Type 2 Diabetes Mellitus in Tribal Population of Bankura, West Bengal, India
Sumanta Banerjee1, Santa Saha (Roy)2, Pinaki Sarkar3, Biswanath Sharma Sarkar4
1Postgraduate Trainee, 2Associate Professor, 3Professor and HOD,
Dept. of Biochemistry, B. S. Medical College, Bankura, West Bengal, India.
4Associate Professor, Dept. of Medicine, B. S. Medical College, Bankura, West Bengal, India.
Corresponding Author: Sumanta Banerjee
ABSTRACT
Diabetes mellitus (DM) is an age-old disease affecting all the organs in the body. More than 90% of DM belongs to type 2 (T2DM). Deterioration of kidney function was noted among diabetic patients in different studies. Microalbuminuria is the earliest reversible change that can be observed in prolonged history of uncontrolled DM. Present study was conducted among the non-addicted tribal participants having blood pressure ≤ 120/80 mm Hg. with or without having antihypertensive medicines, to see whether microalbuminuria was happening due to impairment of glycemic status, chronicity of diabetes etc. It was found that microalbuminuria (estimated by Albumin: Creatinine Ratio, ie, ACR) was found to be worsen with the chronicity of DM and increased HbA1c level. ACR was positively and significantly correlated with age, chronicity and HbA1c level and showed negative significant correlation with Estimated Glomerular Filtration Rate (eGFR). eGFR was found to be significantly deteriorated with age, chronicity, uncontrolled glycemic status (HbA1c level) and Body mass index (BMI).
Key words: ACR, BMI, diabetes mellitus, eGFR, HbA1c, T2DM.
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