Original Research Article
Year: 2018 | Month: August | Volume: 5 | Issue: 8 | Pages: 92-96
Study of Hemoglobin E Disorders in College Students
Dr. Lalpeklawm Hmar1, Dr. Shrabani Barman2, Dr. Jyotismita Deka3
1Medical Officer, Salchapra MPHC, Salchapra, Dict.Cachar, Assam Pin. 788801
2Professor and Head, 3Associate Professor,
Department of Physiology, Silchar Medical College, Silchar, Assam, Pin.788014
ABSTRACT
Introduction: HbE is very common among the ethnic groups of the North East India having cultural and linguistic affiliation with the people of South east Asian countries. HbE occurs in three forms, heterozygous (HbAE), homozygous (HbEE) and the double heterozygous (HbE- β –thalassemia)form. The heterozygous (HbAE) and homozygous (HbEE) forms may be asymptomatic or mildly anemic with red cell indices showing microcytic and hypochromic type but the double heterozygous (HbE- β –thalassemia) presents with various severity from complete lack of symptom to transfusion dependent. Thus, study of HbE variants by Hb typing is of crucial importance to prevent these inherited blood disorders.
Materials and Method: In the present study a total of 50 subjects both male and female in the age group of 18-24 years of under graduate students of Silchar Medical College, Silchar were included in the study. Hb typing was done by electrophoresis at alkaline pH 8.5 using cellulose acetate membrane and complete hemogram analysis done by Sysmex 5 part hematology analyzer.
Results & Observation: A total of 50 subjects studied showed 15 subjects abnormal hemoglobin and 35 subjects normal Hb type. Out of that abnormal hemoglobin, 13 subjects were HbE variants. HbAE being the most common variety with incidence of 9(18%) followed by HbEE 3(6%) and HbE- β –thalassemia 1(2%).
Conclusion: HbE variants were very common among the students of Silchar Medical College. As it is an inherited blood disorders identification of the healthy carries is very important to prevent occurrence of more serious hemoglobinopathies in the future generation.
Key words: hemoglobinopathies, HbE, electrophoresis, red cell indices, anemia.
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