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Original Research Article

Year: 2018 | Month: August | Volume: 5 | Issue: 8 | Pages: 133-139

Comparison of High Dose and Low Dose Calcium Intake to Prevent Preeclampsia and Eclampsia

Dr.S.Parveen¹, Dr.T.Lakshmi Suseela², C.Yojitha³, K.Bhargavi³, M.Deepti³, S.Devasree³, V. Harika³

¹Assisstant Professor, Department of Pharmacy Practice, ³Pharm.D Interns, P. Ramireddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh
²Professor and HOD, Department of Obstetrics and Gynaecology, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh

ABSTRACT

Preeclampsia is a condition, which is the combination of raised blood pressure and proteinuria levels, occurs after 20 weeks of gestation, which leads to maternal complications (eclampsia) and fetal complications. According to worldwide epidemiology the incidence of preeclampsia is reported to be 8-10% among pregnant women. Current WHO recommendations are 1.5–2 g/day calcium supplementation for low-calcium intake pregnant women to prevent complications. The main aim of our study is to compare the high dose & low dose calcium intake to prevent preeclampsia & eclampsia. A prospective Interventional study was performed in south Indian tertiary care teaching hospital for about 6 months [August 2017-january 2018].We had recruited 60 pregnant women and were divided in to two groups:group A[low dose,500 mg, BID] and group B[high dose,500 mg, TID] based on simple randomization technique. After collection of patient data, both the groups were followed for 4 follow ups and Hb, proteinuria levels and Blood Pressure were monitored. Our study results shows that average mean Blood Pressure in low dose group was 109.33/72.66 and 110.33/76.33 and high dose was 125.00/84.33 and 104.333/69.667 before and after treatment respectively .By using SPSS Software results were analysed. By this comparison, we found extreme statistical significant difference between low dose Vs high dose calcium supplementation. Low dose calcium group has poor statistical significance [systole(p<0.586) ,diastole(0.125)],where as high dose calcium group shows extreme statistical significance[systole(p<0.0001),diastole(p<0.0002)].Finally, we may conclude that high dose calcium supplementation is preferable than that of the low dose calcium in preventing the Preeclampsia and Eclampsia.

Key words: Preeclampsia, Eclampsia, Calcium, Blood Pressure, Proteinuria

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