Review Paper
Year: 2018 | Month: August | Volume: 5 | Issue: 8 | Pages: 50-56
A Review on the Probable Reasons and Effects of Abnormal Mitotic Cell Division in Animal
Riyad Hossen
Lecturer, Faculty of Biosciences, Department of Botany, University of Barisal, Bangladesh.
ABSTRACT
Abnormalities in mitosis refer the deviations of normal mitotic cell division. Many different diseases are occurred in animal due to different types of mitotic abnormalities. Researchers successfully indentified some specific reasons for these types of abnormalities. Some cancers in human and mice is the result of such type of diseases which caused by spindle orientation defects and leads to an imbalance of symmetric and asymmetric cell division. A number of gene deletions or mutations classically associated with impaired spindle orientation in mammals and caused ciliopathies. At the current time scientists also suggest that only spindle orientation defects are not main causes of these diseases it also associated with gene mutations and the mutations linked with defects orientation. Mutant LA is another important causal agent for mitotic abnormality which is responsible for Hutchinson–Gilford Progeria Syndrome. Moreover, trisomy and tetrasomy are produced from abnormal segregation of chromosomes due to multipolarity in mitosis which lead to cancers in human. Gisselsson et al give a model for cancers with trisomies by working on Wilms tumor and this model shows how multiple trisomies can produce in tumor cells maintaining accurate sister chromatid separation at metaphase–anaphase transition. Moreover, micronucleus is formed from a lagging chromosome or fragment of a chromosome that fails to incorporate into the main nucleus and causes cancers in animal.
Key words: Abnormal mitosis, cell division, multipolar mitosis, non-disjunction.
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