IJRR

International Journal of Research and Review

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Short Communication

Year: 2018 | Month: September | Volume: 5 | Issue: 9 | Pages: 5-9

Rate Pressure Product in Diabetic Cardiac Autonomic Neuropathy at Rest and Under Stress

Dr. Rishu Segan1, Dr. Lily Walia2, Dr. Naveen Mittal3

1Associate Prof, Deptt. Of Physiology, DRRKGMC, Hamirpur,
2Prof & Head, Deptt. Of Physiology, Pt. JLNGMC, Chamba,
3Professor, Deptt. Of Medicine (Endocrinology), DMC&H, Ludhiana

Corresponding Author: Dr. Rishu Segan

ABSTRACT

Introduction: Rate pressure product, a non invasive indicator of myocardial oxygen demand tends to increase with stress. This determinant is less studied in diabetic cardiac autonomic neuropathy patients both at rest and after stress. An insight into this determinant of myocardial oxygen demand in diabetic cardiac autonomic neuropathy patients may explain sudden adverse cardiovascular events in such patients.
Methods: Case control study (n=45) was done on thirty age matched (40-60 yr) type 2 diabetics with/ without diabetic cardiac autonomic neuropathy and fifteen controls for rate pressure product.
Results: Results demonstrated (ANOVA and paired ‘t’ – test, ‘SPSS’ software) that resting rate pressure product was significantly increased in cardiac autonomic neuropathy patients (p< 0.05) and out of normative zone (>12) pushing these patients into risk zone for adverse cardiovascular events. The stress rate pressure product was similar to resting showing little or no increment demonstrating a non significant result (p>0.01)
Conclusion: Diabetic cardiac autonomic neuropathy significantly increases resting rate pressure product and inversely affects stress related increment for same.

Key words: Rate pressure product, Myocardial oxygen demand, Diabetic cardiac autonomic neuropathy,

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